Restylane Refyne is an injectable filler used to treat moderate to severe “laugh lines” around the mouth. Restylane Refyne is designed with XpresHAn Technology™ to help soften laugh lines (nasolabial folds and marionette lines). This can help you restore a more natural look to your face while maintaining your facial expressions. So, you always look like you. Results last up to 12 months.